Advances In Respiratory Medicine Research Articles

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From the Literature

HomeCirculationVol. 144, No. 18From the Literature Free AccessNewsPDF/EPUBAboutView PDFView EPUBSections ToolsAdd to favoritesDownload citationsTrack citationsPermissions ShareShare onFacebookTwitterLinked InMendeleyReddit Jump toFree AccessNewsPDF/EPUBFrom the Literature Tracy Hampton, PhD Tracy HamptonTracy Hampton Search for more papers by this author Originally published1 Nov 2021https://doi.org/10.1161/CIRCULATIONAHA.121.057645Circulation. 2021;144:1516–1517New Research Charts Metabolism Through the Human Life CourseIn a study of individuals from 8 days to 95 years of age, investigators have completed the first clear roadmap of metabolism across the lifespan, with distinct phases—for neonates, juveniles, adults, and older adults—throughout development and aging. The new findings could be used to shape nutrition and health strategies that are tailored to different life stages.For the study, which is published in Science, a large international collaborative team used the double-labeled water method, a technique based on the relative bodily elimination rates of isotopes of oxygen and hydrogen, to analyze total daily energy expenditure in 6421 males and females from 29 countries across the globe.The resultant trajectory of metabolism revealed that newborns have metabolic rates like small adults, burning the number of calories each day that would be expected for a small human. Metabolism skyrockets in the first year of life, however, and then remains high through childhood, declining slowly through adolescence until ≈20 years of age. Surprisingly, there is no metabolic spike at puberty. Next, from age 20 years to 60 years, metabolism is very stable, with no middle-age slowdown, contrary to conventional wisdom, and no apparent impact of menopause, which was also a surprise. After 60 years of age, metabolism begins to decline, not because of loss of muscle mass at older ages (as analyses accounted for fat-free mass and fat mass), but because the body’s cells slow down as individuals age beyond their sixth decade.Download figureDownload PowerPointAnalyses of >6000 individuals around the world, with ages ranging from very young to very old, reveal distinct metabolic changes that occur during a human’s life.“A lot of noncommunicable diseases, including cardiovascular disease, become more common as people age beyond 60 years. Some of this disease risk could be related to declines in cellular activity, either as a cause or consequence,” said lead author Dr Herman Pontzer, of Duke University. “Metabolic rates could therefore be a useful biomarker of risk, and cellular energy metabolism could be a target for therapies to mitigate age-related decline.”Pontzer H et al. Daily energy expenditure through the human life course. Science. 2021;373:808–812. doi: 10.1126/science.abe5017Ongoing Trial Tests Gene Editing Therapy in Patients With Transthyretin AmyloidosisFor the first time, scientists have shown that a CRISPR-Cas9–based therapy can be administered by intravenous infusion and edit a gene within the human body—in this case, the mutated TTR gene that causes transthyretin amyloidosis, a disease in which the transthyretin protein that is produced by liver cells misfolds and aggregates in the nerves and heart.The therapy, called NTLA-2001, consists of a liver-targeting lipid nanoparticle delivery system that encapsulates the mRNA for Cas9 protein and a single guide RNA targeting TTR. The treatment leads to a decrease in the production of both wild-type and mutant transthyretin after a single administration. In the investigators’ previous research in mice and cynomolgus monkeys, a single dose of NTLA-2001 led to durable reductions in blood levels of the protein by 95% or more.As described in The New England Journal of Medicine, the team is now testing the potential of single escalating doses of NTLA-2001 in patients with hereditary transthyretin amyloidosis with polyneuropathy. They reported 6 patients, 3 in each of the 2 initial dose groups (0.1 and 0.3 mg/kg).In this ongoing phase 1 clinical study, NTLA-2001 administration has been associated with only mild adverse events and manifested dose-dependent pharmacodynamic effects. At day 28, the average reduction from baseline in serum transthyretin protein concentration was 52% in the group that received a dose of 0.1 mg/kg and 87% in the group that received a dose of 0.3 mg/kg.“Interim data showed that the therapy was well tolerated in the short term and achieved a dose-dependent knockdown of circulating transthyretin concentration of up to 96%. This is expected to translate into real clinical benefit for patients,” said lead author Dr Julian Gillmore, of University College London. “Whilst this study establishes that through packaging within a lipid nanoparticle, a CRISPR-Cas9 therapeutic can be successfully delivered to the liver and target a specific gene within hepatocytes for editing, the challenge of delivery of the therapy to other cell types remains the cornerstone of its wide application in medicine and revolutionary potential to treat human disease.”Gillmore JD et al. CRISPR-Cas9 in vivo gene editing for transthyretin amyloidosis. N Engl J Med. 2021;385:493–502. doi: 10.1056/NEJMoa2107454Gene Editing May Treat Cardiomyopathy in Duchenne Muscular DystrophyUsing CRISPR/Cas9 gene editing techniques, investigators recently reduced heart abnormalities in human and mouse models of Duchenne muscular dystrophy (DMD), an X-linked condition characterized by degeneration of skeletal and cardiac muscles.The achievement is timely because current therapies only slow the progression of heart disease. Also, cardiomyopathy has become a more significant concern for patients with DMD because advances in respiratory medicine have addressed the neuromuscular aspects of the disease that lead to respiratory failure.The study, which is published in Circulation Research, involved induced pluripotent stem cells from a patient with DMD and his healthy brother, as well as from a mouse model of DMD. The patient had a deletion in exon 44 of the DMD gene, and the team used CRISPR/Cas9 editing to correct the reading frame of the gene by either reframing or exon skipping.Cardiomyocytes obtained from DMD induced pluripotent stem cells, in which the reading frame was restored using either reframing or exon skipping, were similar to control cardiomyocytes in terms of morphology, structure, and function.In RNA sequencing analyses, cardiomyocytes derived from DMD induced pluripotent stem cells showed transcriptional dysregulation consistent with dilated cardiomyopathy. This dysregulation was reduced in cardiomyocytes from DMD induced pluripotent stem cells in which the reading frame of the DMD gene was restored.Also, CRISPR/Cas9-based correction of dysfunctional DMD cardiomyocytes after differentiation reduced the cells’ propensity for arrhythmia. Finally, results from in vivo experiments suggested that gene editing may target heart abnormalities in mice with a DMD mutation.“CRISPR/Cas9 genome editing has gained significant traction as a potential therapeutic tool for DMD over the past decade,” the authors wrote. “These findings provide key insights into the utility of genome editing as a novel therapeutic for DMD-associated cardiomyopathy.”Atmanli A et al. Cardiac myoediting attenuates cardiac abnormalities in human and mouse models of Duchenne muscular dystrophy. Circ Res. 2021;129:602–616. doi: 10.1161/CIRCRESAHA.121.319579FootnotesThe opinions expressed in this article are not necessarily those of the editors or of the American Heart Association.https://www.ahajournals.org/journal/circ Previous Back to top Next FiguresReferencesRelatedDetails November 2, 2021Vol 144, Issue 18 Advertisement Article InformationMetrics © 2021 American Heart Association, Inc.https://doi.org/10.1161/CIRCULATIONAHA.121.057645 Originally publishedNovember 1, 2021 PDF download Advertisement

Letter from the Editor

This is a great pleasure to announce, that Advances in Respiratory Medicine has been recently approved for Emerging Sources Citation Index (ESCI) [...]

Editors Note

The Editors of Advances in Respiratory Medicine would like to warmly welcome new members of the Scientific Advisory Board. Our invitation to join the Board was kindly accepted by Professor Christer Janson and Professor Raffaele Antonelli Incalzi [...]

Change of the Title: “Pneumonologia i Alergologia Polska” Becomes “Advances in Respiratory Medicine”

Since 2015 we have introduced several changes to our Journal [...]

Editorial introductions

Current Opinion in Pulmonary Medicine was launched in 1995. It is one of a successful series of review journals whose unique format is designed to provide a systematic and critical assessment of the literature as presented in the many primary journals. The field of pulmonary medicine is divided into nine sections that are reviewed once a year. Each section is assigned a Section Editor, a leading authority in the area, who identifies the most important topics at that time. Here we are pleased to introduce the Journal's Editors and Section Editors for this issue. EDITORS IN CHIEF Robert BaughmanRobert BaughmanDr Robert Baughman is Professor of Medicine at the University of Cincinnati, USA. After completing undergraduate training at Yale University, USA, he received his medical degree from Case Western Reserve School of Medicine, USA. He joined the Internal Medicine staff at the University of Cincinnati after completing both an internal medicine residency and fellowship training in pulmonary diseases at the University of Cincinnati. His major research interests include: the treatment of sarcoidosis and bronchoalveolar lavage. Along with his long-time collaborator Dr Elyse Lower, he has developed several novel treatments for sarcoidosis, including methotrexate, thalidomide, leflunomide, and infliximab. Current studies include treatments for sarcoidosis associated fatigue and pulmonary hypertension due to sarcoidosis. He is on the editorial board of multiple subspecialty journals, and his publications include over 150 original papers and over 70 review articles and/or book chapters. He is on the editorial board of several journals, including American Journal of Respiratory and Critical Care Medicine and Chest. He is co-Editor of the journal Sarcoidosis, Interstitial Lung Disease, and Vasculitis and serves on the editorial board of several other journals, including Chest and American Journal of Respiratory and Critical Care Medicine. In addition, Dr Baughman is the editor of books on sarcoidosis, interstitial lung disease, and ventilator associated pneumonia. Marjolein DrentMarjolein DrentDr Marjolein Drent studied physical therapy at the Arnhem Academy of Physical Therapy, the Netherlands. She finished her medical study in 1988 at the Catholic University of Nijmegen. In 1993 she completed her thesis entitled: ‘Diagnostic value of bronchoalveolar lavage in interstitial lung diseases.’ After she finished her training as a pulmonologist she was appointed at the Department of Respiratory Medicine of the Maastricht University Medical Centre (MUMC), from 1994 to 2012. In December 2005 she was appointed as Professor of Interstitial Lung Diseases (ILD). Her oration was entitled: ‘Breathtaking inspirations…’ Currently, she is the manager of the ILD care team at Gelderse Vallei Hospital, Ede, the Netherlands. She is involved in clinical, biochemical and genetic research into inflammation focusing on ILD, including occupational and environmental related disorders, pharmacogenomics, translational medicine and e-health. Prevention became one of the main themes in her research. She collaborates with international ILD experts. She is the current President-Elect of the WASOG (World Association of Sarcoidosis and other Granulomatous diseases; see www.wasog.org). She is Associate Editor of Sarcoidosis Vasculitis and Diffuse Lung Diseases. She is a co-Editor and guest Editor of several sarcoidosis issues of international journals. She is a reviewer of many international journals. She has (co-) authored over 300 papers and book chapters. Furthermore, she is concerned with several educational assignments, organisation of postgraduate courses and clinical trials. She was a member of many scientific committees of national and international conferences, an invited speaker and a chair at these meetings. In 2011 she organized the second combined 10th WASOG Meeting and the 12th International Conference on BAL in Maastricht. She is the founder and chair of the ild care (interstitial lung diseases including sarcoidosis and lung diseases related to occupation and environment management and research) foundation (see www.ildcare.eu) She is an honorary member of the SBN (Dutch Sarcoidosis Society) and founder and a member of the advisory board of the Dutch Pulmonary Fibrosis Society. In 2007 she received the Novartis Pulmonology award because of her dedication to achieve improvement of the quality of life of patients. In January 2011 and 2012 she was selected as the leading physician by her colleague Dutch pulmonary doctors. In November 2012 she was nominated as ‘World Sarcoidosis Person of the Year Award’. This award is selected by patients of the Irish Sarcoidosis Support Network (ISarc) for her tireless research work in defining the psychological burden faced by patients and their families (Dublin, Ireland). SECTION EDITORS Nicola A. HananiaNicola A. HananiaDr Nicola A. Hanania received his Bachelor of Medicine and Surgery degree and a Master of Science degree in internal medicine from the University of Jordan, Amman, Jordan. He then completed his residency in internal medicine at the University of Jordan, followed by a residency in internal medicine and a fellowship in pulmonary medicine at the University of Toronto, Canada. Dr Hanania then completed a research fellowship at the Asthma Center of the Toronto Hospital, followed by a fellowship in critical care medicine at Baylor College of Medicine in Houston, Texas, USA. He also received a Master of Science degree in clinical investigations from Baylor College of Medicine. He is certified in internal medicine, pulmonary medicine and critical care medicine. Dr Hanania joined the faculty at Baylor College of Medicine (BCM) in Houston, Texas in 1995 as an Assistant Professor of Medicine in the Department of Medicine, Section of Pulmonary and Critical Care Medicine. He is currently Associate Professor of Medicine and Director of the Asthma Clinical Research Center at BCM. He is also Director of the Asthma Adult Clinic and Pulmonary Diagnostic services at Ben Taub General Hospital in Houston, Texas. Dr Hanania is a fellow of the American College of Chest Physicians, the American College of Physicians and the Royal College of Physicians and Surgeons of Canada, as well as member of many professional societies, including the American Thoracic Society and the Society of Critical Care Medicine. He has served as Chair, Council of Networks of the American College of Chest Physicians (ACCP) and as a member of the executive committee and board of regents of ACCP and the National Asthma Education Certification Board (NAECB). Dr Hanania is the recipient of the Fulbright and Jaworski Faculty Excellence Award in Teaching and Evaluation, an Outstanding Teacher Award in the Department of Medicine, and an Attending of the Year Award in the Pulmonary and Critical Care Section at Baylor College of Medicine. Dr Hanania is principal investigator for the American Lung Association Asthma Clinical Research Center and Center Director for the COPD gene study at Baylor College of Medicine. He is also principal investigator or co-investigator of several clinical trials in asthma and COPD. His research is funded by NIH, American Lung Association and industry. His research focus is on beta2-agonists and on novel therapies for asthma and COPD. He has published and edited numerous articles, book chapters, reviews and abstracts. Dr Hanania has been an invited to lecture or chair sessions at many local, national, and international meetings. Dr Hanania is currently deputy Editor of Respiratory Medicine and associate Editor of Therapeutic Advances in Respiratory Medicine (TARD). In addition, he is an ad-hoc reviewer for several other journals including European Respiratory Medicine, Chest, Drugs, Pulmonary Pharmacology and Therapeutics and the American Journal of Respiratory Critical Care Medicine. Zuzana DiamantZuzana DiamantZuzana Diamant is pulmonologist and clinical pharmacologist, currently affiliated as Guest Professor of Asthma & Allergy Research at the Institute for Clinical Science of the Skane University in Lund, Sweden. She is also associated as a senior scientist with the Department of General Practice at University Medical Center of Groningen, the Netherlands, and acts as Director of Respiratory & Allergy Research for QPS-Netherlands. In 1996, Dr Diamant acquired her PhD at Leiden University, the Netherlands (thesis: ‘Experimental interventions in leukotriene- and allergen-induced airway responses in asthma in vivo’). For over 20 years, Dr Diamant has been involved in setting up and the performance of clinical research in asthma and allergy focusing on pathophysiological mechanisms, biomarkers and inflammatory disease models. In the past 10 years, Dr Diamant set up several respiratory research units in close collaboration with academic centers of excellence and served both as research director and principle investigator in innovative drug development for respiratory diseases. Dr Diamant has an interest in identifying novel targets and biomarkers and investigating novel treatment modalities with a focus on asthma and allergy. Apart from her research activities, Dr Diamant is involved in several advisory boards on biomarkers, she teaches on clinical respiratory research and GCP, and she is an active member of an ATS/ERS task force on Bronchoprovocation testing (focus: inhaled allergen challege) and of a newly formed EAACI task force on Biomarkers & Outcomes. She has published over 90 articles in scientific journals and books, she also serves as an Associate Editor at Respiratory Medicine, Pulmonary Pharmacology & Therapeutics and European Clinical Respiratory Journal and is a member of several (inter)national professional societies.

Editorial introductions

Current Opinion in Pulmonary Medicine was launched in 1995. It is one of a successful series of review journals whose unique format is designed to provide a systematic and critical assessment of the literature as presented in the many primary journals. The field of pulmonary medicine is divided into nine sections that are reviewed once a year. Each section is assigned a Section Editor, a leading authority in the area, who identifies the most important topics at that time. Here we are pleased to introduce the Journal's Section Editor for this issue. EDITORS IN CHIEF Robert BaughmanRobert BaughmanDr Robert Baughman is Professor of Medicine at the University of Cincinnati, USA. After completing undergraduate training at Yale University, USA, he received his medical degree from Case Western Reserve School of Medicine, USA. He joined the Internal Medicine staff at the University of Cincinnati after completing both an internal medicine residency and fellowship training in pulmonary diseases at the University of Cincinnati. His major research interests include: the treatment of sarcoidosis and bronchoalveolar lavage. Along with his long time collaborator Dr Elyse Lower, he has developed several novel treatments for sarcoidosis, including methotrexate, thalidomide, leflunomide, and infliximab. Current studies include treatments for sarcoidosis associated fatigue and pulmonary hypertension due to sarcoidosis. He is on the editorial board of multiple subspecialty journals, and his publications include over 150 original papers and over 70 review articles and/or book chapters. He is on the editorial board of several journals, including American Journal of Respiratory and Critical Care Medicine and Chest. He is co-Editor of the journal Sarcoidosis Vasculitis and Diffuse Lung Diseases and serves on the editorial board of several other journals, including Chest and American Journal of Respiratory and Critical Care Medicine. In addition, Dr Baughman is the editor of books on sarcoidosis, interstitial lung disease, and ventilator associated pneumonia. Marjolein DrentMarjolein DrentDr Marjolein Drent studied physical therapy at the Arnhem Academy of Physical Therapy, the Netherlands. She finished her medical study in 1988 at the Catholic University of Nijmegen, NL. In 1993 she completed her thesis entitled: ‘Diagnostic value of bronchoalveolar lavage in interstitial lung diseases.’ After she finished her training as a pulmonologist she was appointed at the Department of Respiratory Medicine of the Maastricht University Medical Centre (MUMC), NL, from 1994 to 2012. In December 2005 she was appointed as Professor of interstitial lung diseases (ild). Her oration was entitled: ‘Breathtaking inspirations…’. Currently, she is the manager of the ild care team at Gelderse Vallei Hospital, Ede, NL. She is involved in clinical, biochemical and genetic research into inflammation focusing on ild, including occupational and environmental related disorders, pharmacogenomics, translational medicine and e-health. Prevention became one of the main themes in her research. She collaborates with international ild experts. She is the current President-Elect of the WASOG (World Association of Sarcoidosis and other Granulomatous diseases; see www.wasog.org). She is Associate Editor of Sarcoidosis Vasculitis and Diffuse Lung Diseases. She is a co-Editor and guest Editor of several sarcoidosis issues of international journals. She is a reviewer of many international journals. She (co-) authored over 300 papers and book chapters. Furthermore, she is concerned with several educational assignments, organisation of postgraduate courses and clinical trials. She was a member of many scientific committees of national and international conferences, an invited speaker and a chair at these meetings. In 2011 she organized the second combined 10th WASOG Meeting and the 12th International Conference on BAL in Maastricht, NL. She is the founder and chair of the ild care (interstitial lung diseases including sarcoidosis and lung diseases related to occupation and environment management and research) foundation (see www.ildcare.eu). She is an honorary member of the SBN (Dutch Sarcoidosis Society) and founder and a member of the advisory board of the Dutch Pulmonary Fibrosis Society. In 2007 she received the Novartis Pulmonology award because of her dedication to achieve improvement of the quality of life of patients. In January 2011 and 2012 she was selected as the leading physician by her colleague Dutch pulmonary doctors. In November 2012 she was nominated as ‘World Sarcoidosis Person of the Year Award’. This award is selected by patients of the Irish Sarcoidosis Support Network (ISarc) for her tireless research work in defining the psychological burden faced by patients and their families (Dublin, Ireland). SECTION EDITORS Nicola A. HananiaNicola A. HananiaDr Nicola A. Hanania received his Bachelor of Medicine and Surgery degree and a Master of Science degree in internal medicine from the University of Jordan, Amman, Jordan. He then completed his residency in internal medicine at the University of Jordan, followed by a residency in internal medicine and a fellowship in pulmonary medicine at the University of Toronto, Canada. Dr Hanania then completed a research fellowship at the Asthma Center of the Toronto Hospital, followed by a fellowship in critical care medicine at Baylor College of Medicine in Houston, Texas, USA. He also received a Master of Science degree in clinical investigations from Baylor College of Medicine. He is certified in internal medicine, pulmonary medicine and critical care medicine. Dr Hanania joined the faculty at Baylor College of Medicine (BCM) in Houston, Texas in 1995 as an Assistant Professor of Medicine in the Department of Medicine, Section of Pulmonary and Critical Care Medicine. He is currently Associate Professor of Medicine and Director of the Asthma Clinical Research Center at BCM. He is also Director of the Asthma Adult Clinic and Pulmonary Diagnostic services at Ben Taub General Hospital in Houston, Texas. Dr Hanania is a fellow of the American College of Chest Physicians, the American College of Physicians and the Royal College of Physicians and Surgeons of Canada, as well as member of many professional societies, including the American Thoracic Society and the Society of Critical Care Medicine. He has served as Chair, Council of Networks of the American College of Chest Physicians (ACCP) and as a member of the executive committee and board of regents of ACCP and the National Asthma Education Certification Board (NAECB). Dr Hanania is the recipient of the Fulbright and Jaworski Faculty Excellence Award in Teaching and Evaluation, an Outstanding Teacher Award in the Department of Medicine, and an Attending of the Year Award in the Pulmonary and Critical Care Section at Baylor College of Medicine. Dr Hanania is principal investigator for the American Lung Association Asthma Clinical Research Center and Center Director for the COPD Gene study at Baylor College of Medicine. He is also principal investigator or co-investigator of several clinical trials in asthma and COPD. His research is funded by NIH, American Lung Association and industry. His research focus is on beta2-agonists and on novel therapies for asthma and COPD. He has published and edited numerous articles, book chapters, reviews and abstracts. Dr Hanania has been an invited to lecture or chair sessions at many local, national, and international meetings. Dr Hanania is currently deputy Editor of Respiratory Medicine and associate Editor of Therapeutic Advances in Respiratory Medicine (TARD). In addition, he is an ad-hoc reviewer for several other journals including European Respiratory Medicine, Chest, Drugs, Pulmonary Pharmacology and Therapeutics and the American Journal of Respiratory Critical Care Medicine. Zuzana DiamantZuzana DiamantZuzana Diamant is pulmonologist and clinical pharmacologist, currently affiliated as Guest Professor of Asthma & Allergy Research at the Institute for Clinical Science of the Skane University in Lund, Sweden. She is also associated as a senior scientist with the Department of General Practice at University Medical Center of Groningen, The Netherlands. For over 20 years, Dr Diamant has performed clinical research of asthma and allergy focusing on pathophysiological mechanisms, biomarkers and inflammatory disease models. In 1996, she acquired her PhD at Leiden University, The Netherlands (thesis: Experimental interventions in leukotriene- and allergen-induced airway responses in asthma in vivo). In the past 10 years, Dr Diamant set up several respiratory research units in close collaboration with academic centers of excellence and served both as research director and principle investigator in innovative drug development for respiratory diseases. Dr Diamant has an interest in identifying novel targets and investigating novel treatment modalities with a focus on asthma and allergy. Apart from her research activities, Dr Diamant is involved in several advisory boards on biomarkers, in teaching on clinical respiratory research and GCP, and she is an active member of an ATS/ERS task force on bronchoprovocation testing (focus: inhaled allergen challege) and of a newly formed EAACI task force on Biomarkers & Outcomes. She also serves as an Associate Editor at Respiratory Medicine and Pulmonary Pharmacology & Therapeutics and is a member of several professional societies.

Editorial introductions

Current Opinion in Pulmonary Medicine was launched in 1995. It is one of a successful series of review journals whose unique format is designed to provide a systematic and critical assessment of the literature as presented in the many primary journals. The field of pulmonary medicine is divided into nine sections that are reviewed once a year. Each section is assigned a Section Editor, a leading authority in the area, who identifies the most important topics at that time. Here we are pleased to introduce the Journal's Editors and Section Editor for this issue. EDITORS-IN-CHIEF Robert BaughmanRobert BaughmanDr Baughman is Professor of Medicine at the University of Cincinnati, USA. After completing undergraduate training at Yale University, USA, he received his medical degree from Case Western Reserve School of Medicine, USA. He joined the Internal Medicine staff at the University of Cincinnati after completing both an internal medicine residency and fellowship training in pulmonary diseases at the University of Cincinnati. His major research interests include: the treatment of sarcoidosis and bronchoalveolar lavage. Along with his long time collaborator Dr Elyse Lower, he has developed several novel treatments for sarcoidosis, including methotrexate, thalidomide, leflunomide, and infliximab. Current studies include treatments for sarcoidosis associated fatigue and pulmonary hypertension due to sarcoidosis. He is on the editorial board of multiple subspecialty journals, and his publications include over 150 original papers and over 70 review articles and/or book chapters. He is on the editorial board of several journals, including American Journal of Respiratory and Critical Care Medicine and Chest. He is co-Editor of the journal Sarcoidosis, Interstitial Lung Disease, and Vasculitis and serves on the editorial board of several other journals, including Chest and American Journal of Respiratory and Critical Care Medicine. In addition, Dr Baughman is the editor of books on sarcoidosis, interstitial lung disease, and ventilator associated pneumonia. Marjolein DrentMarjolein DrentDr Marjolein Drent studied physical therapy at the Arnhem Academy of Physical therapy, the Netherlands (NL). She finished her medical study in 1988 at the Catholic University of Nijmegen, NL. In 1993 she completed her thesis entitled: ‘Diagnostic value of bronchoalveolar lavage in interstitial lung diseases.’ She finished her training as a pulmonologist at the Saint Antonius Hospital (Nieuwegein, NL) in 1994. She was appointed at the Department of Respiratory Medicine of the Maastricht University Medical Centre (MUMC), NL, from 1994 to 2012. In December 2005 she was appointed as Professor of interstitial lung diseases (ild). Her oration was entitled: ‘Breathtaking inspirations…’. She is the manager of the ild care team first located at the MUMC+, and since 2012 at Hospital Gelderse Vallei, Ede, NL. Currently, she is involved in clinical, biochemical and genetic research into inflammation focusing on ild, including occupational and environmental related disorders, pharmacogenomics, translational medicine and e-health. Prevention became one of the main themes in her research. She collaborates with international centers famous for ild. She is an honorary member of the SBN (Dutch Sarcoidosis Society) and founder and a member of the advisory board of the Dutch Pulmonary Fibrosis Society. In 2007 she received the Novartis Pulmonology award. This was awarded by a national jury because of her dedication to achieve improvement of the quality of life of patients. In January 2012 she was selected as the leading physician of 2011 by her colleague Dutch pulmonary doctors. In November 2012 she was nominated as ‘World Sarcoidosis Person of the Year Award’. This award is selected by patients of the Irish Sarcoidosis Support Network (ISarc) for her tireless research work in defining the psychological burden faced by patients and their families (Dublin, Ireland). She is the founder and chair of the ild care (interstitial lung diseases including sarcoidosis and lung diseases related to occupation and environment management and research) foundation (see http://www.ildcare.eu). Furthermore, she is concerned with several educational assignments, organisation of postgraduate courses and clinical trials. She was a member of many scientific committees of national and international conferences, an invited speaker and a chair at these meetings. In 2011 she organized the second combined 10th WASOG Meeting and the 12th International Conference on BAL in Maastricht (NL). She is the current President-Elect of the WASOG (World Association of Sarcoidosis and other Granulomatous diseases; see http://www.wasog.org). She is Associate Editor of Sarcoidosis Vasculitis and Diffuse Lung Diseases. She is a co-editor ad guest editor of several sarcoidosis issues of international journals. She is a reviewer of many international journals. She has (co-) authored over 250 papers and book chapters. SECTION EDITOR Nicola A. HananiaNicola A. HananiaDr Nicola (Nick) A. Hanania received his Bachelor of Medicine and Surgery degree and a Master of Science degree in internal medicine from the University of Jordan, Amman, Jordan. He then completed his residency in internal medicine at the University of Jordan, followed by a residency in internal medicine and a fellowship in pulmonary medicine at the University of Toronto, Canada. Dr Hanania then completed a research fellowship at the Asthma Center of the Toronto Hospital, followed by a fellowship in critical care medicine at Baylor College of Medicine in Houston, Texas, USA. He also received a Master of Science degree in Clinical Investigations from Baylor College of Medicine. He is certified in internal medicine, pulmonary medicine and critical care medicine. Dr Hanania joined the faculty at Baylor College of Medicine (BCM) in Houston, Texas in 1995 as an Assistant Professor of Medicine in the Department of Medicine, Section of Pulmonary and Critical Care Medicine. He is currently Associate Professor of Medicine and Director of the Asthma Clinical Research Center at BCM. He is also Director of the Asthma Adult Clinic and Pulmonary Diagnostic services at Ben Taub General Hospital in Houston, Texas. Dr Hanania is a fellow of the American College of Chest Physicians, the American College of Physicians and the Royal College of Physicians and Surgeons of Canada, as well as member of many professional societies, including the American Thoracic Society and the Society of Critical Care Medicine. He has served as Chair, Council of Networks of the American College of Chest Physicians (ACCP) and as a member of the executive committee and board of regents of ACCP and the National Asthma Education Certification Board (NAECB). Dr Hanania is the recipient of the Fulbright and Jaworski Faculty Excellence Award in Teaching and Evaluation, an Outstanding Teacher Award in the Department of Medicine, and an Attending of the Year Award in the Pulmonary and Critical Care Section at Baylor College of Medicine. Dr Hanania is principal investigator for the American Lung Association Asthma Clinical Research Center and Center Director for the COPD Gene study at Baylor College of Medicine. He is also principal investigator or co-investigator of several clinical trials in asthma and COPD. His research is funded by NIH, American Lung Association and industry. His research focus is on beta2-agonists and on novel therapies for asthma and COPD. He has published and edited numerous articles, book chapters, reviews and abstracts. Dr Hanania has been invited to lecture or chair sessions at many local, national, and international meetings. Dr Hanania is currently Deputy Editor of Respiratory Medicine and Associate Editor of Therapeutic Advances in Respiratory Medicine (TARD). In addition, he is an ad-hoc reviewer for several other journals including European Respiratory Medicine, Chest, Drugs, Pulmonary Pharmacology and Therapeutics and the American Journal of Respiratory Critical Care Medicine.

Advances in Respiratory Medicine

Advances in Respiratory Medicine

Advances in respiratory medicine

Advances in respiratory medicine

Current status of noninvasive ventilation in stable COPD patients

Noninvasive ventilation (NIV) has been one of the major advances in respiratory medicine in the last decade. NIV improves quality of life, prolongs survival, and improves gas exchange and sleep quality in restrictive patients, but evidence available now does not allow us to establish clear criteria for prescribing NIV in patients with chronic respiratory failure due to COPD. On the basis of the available studies, NIV should not be used as a treatment of choice for all patients with COPD, even when disease is severe. However, there is more evidence that NIV has an important effect in these patients. In fact, a selected group of patients may well benefit from domiciliary mechanical ventilation, and we need to be able to identify who they are. Moreover, NIV can be a new strategy to improve exercise tolerance in COPD patients.

Recent Advances in Respiratory Medicine

Recent Advances in Respiratory Medicine

Recent Advances in Respiratory Medicine

Recent Advances in Respiratory Medicine

Recent Advances in Respiratory Medicine

Recent Advances in Respiratory Medicine

Recent advances in respiratory medicine.

Summary In the past tuberculosis so dominated both public and professional views of respiratory medicine that it seemed obvious that the speciality must atrophy, at least in developed countries, when effective therapy for tuberculosis became available. The reality has been rather different. New discoveries in understanding of pathogenesis, in diagnostic methods, and above all in treatment, continue to keep respiratory medicine to the fore amongst the major sub-specialities of medicine, a position that the burden of such disease on society clearly merits. The topics chosen for this review are necessarilv personal, but aim to indicate some areas where these discoveries are being applied in clinical practice today.

Recent Advances in Respiratory Medicine

Recent Advances in Respiratory Medicine

Lung Diseases: State of the Art 1975-1976

<b>Recent Advances in Respiratory Medicine,</b>No. 1, edited by T. B. Stretton, 311 pp, with illus, $32,50, New York, Churchill Livingstone, 1976. Recently two books have appeared whose stated purpose is to give physicians interested in pulmonary disease a succinct overview of new developments. In the United States, the American Thoracic Society, with John Murray as editor, has published the second volume in the series "Lung Disease: State of the Art." Twelve essays, all of which have appeared in the<i>American Review of Respiratory Disease</i>, have been chosen for publication. The subjects, ranging from occupational lung disease to "General Anesthesia and the Lung," are comprehensive in detail and written by authorities in their field. The quality of photomicrograph and xray reproduction is excellent, while the diagrams are explicit. The essays are of the highest quality, and the price is modest for this high-quality volume. Since these essays are accessible separately

Recent Advances in Respiratory Medicine

Recent Advances in Respiratory Medicine

Pulmonary edema in dogs, especially the sequence of fluid accumulation in lungs.

ArticlePulmonary edema in dogs, especially the sequence of fluid accumulation in lungs.N C Staub, H Nagano, and M L PearceN C Staub, H Nagano, and M L PearcePublished Online:01 Feb 1967https://doi.org/10.1152/jappl.1967.22.2.227MoreSectionsPDF (4 MB)Download PDF ToolsExport citationAdd to favoritesGet permissionsTrack citations ShareShare onFacebookTwitterLinkedInWeChat Previous Back to Top Next Download PDF FiguresReferencesRelatedInformation Cited ByDiagnosing Lung Abnormalities Related to Heart Failure in Chest Radiogram, Lung Ultrasound and Thoracic Computed Tomography23 February 2023 | Advances in Respiratory Medicine, Vol. 91, No. 2Vertical Artifacts as Lung Ultrasound Signs: Trick or Trap? 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